All my work ends up on the computer, drawn with a Wacom Intuos pen tablet in Photoshop with some custom brushes I fiddled with myself. :]
Of course, using traditional media is a great way to build up a collection of great textures you can use to make your digital work look more natural. Which is something I mean to do more of, with inks and watercolors.
My last political cartoon did really well. Now for the hard part. Doing it again.